Nanobioceramics for Bone Tissue Engineering and Regenerative Biomedicine

This book examines the tunable biological characteristics of nanobioceramics and addresses key challenges in bone tissue engineering and regenerative medicine. It explains how synthetic composite-based materials and scaffolds can be designed to be biodegradable, biocompatible, and structurally supportive for cell migration, oxygen, waste, and nutrient carriage that accelerates bone regeneration and remodeling in defects.

The text details how tunable physical features such as absorption rate, degradation rate, modulus, porosity, and swelling can be adjusted through the addition of ceramic phases and copolymers in synthetic composite scaffolds. It also covers synthetic bioceramics that imitate natural hydroxyapatite crystal formation in bone, particularly calcium phosphates, which have demonstrated osteoinductivity, osteoconductivity, and biocompatibility.

Silicon-based glass-ceramics are explored as an alternative to calcium phosphates, with members of this class exhibiting high bioactivity, attractive mechanical strength, and the ability to increase cell proliferation, adhesion, and mineralization of extracellular matrix. The antibacterial properties of some nanostructured bioceramics are also discussed in relation to avoiding implant rejection in surgery and biomedicine.

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